Rifampicin/Isoniazid/Ethambutol hydrochloride 150mg/75mg/275mg Tablets  

Anti-tuberculous

COMPOSITION:

Each Tablet contains 150 mg rifampicin 75 mg isoniazid and 275mg Ethambutol .

INDICATIONS:

Tablets is indicated for the initial treatment of tuberculosis.

Do not take Rifampicin/Isoniazid/Ethambutol hydrochloride 150mg/75mg/275mg Tablets: 
- if you are hypersensitive (allergic) to isoniazid, rifampicin, ethambutol or any of the other 
ingredients of Rifampicin/Isoniazid/Ethambutol hydrochloride 150mg/75mg/275mg Tablets (see 
section 6, What Rifampicin/Isoniazid/Ethambutol hydrochloride 150mg/75mg/275mg Tablets 
contains). 
- if you have acute liver disease, 
- if you have drug-induced liver disease, 
- if you have experienced liver damage linked to isoniazid or rifampicin before, 
- if you have experienced severe side effects of isoniazid or rifampicin, such as drug fever or chills. 
- if you have inflammation of the optic nerve (optic neuritis) 
- if you are using voriconazole (a medicine used to treat fungal infections) or a medicine against 
HIV infection that belongs to the class of protease inhibitors. 

DOSAGE AND DIRECTIONS FOR USE:

Rifampicin/Isoniazid/Ethambutol hydrochloride 150mg/75mg/275mg Tablets should always be taken 
exactly as described by the doctor or health care provider. You should check with your doctor, health 
care provider or pharmacist if you are not sure. 
The dose of Rifampicin/Isoniazid/Ethambutol hydrochloride 150mg/75mg/275mg Tablets is decided 
on the basis of your body weight. 
For a child weighing 21-30 kg, give 2 tablets daily (Only for children who can swallow solid tablets.) 
If you weigh 30-39 kg, take 2 tablets daily. 
If you weigh 40-54 kg, take 3 tablets daily. 
If you weigh 55-70 kg, take 4 tablets daily 
If you weigh above 70 kg, take 5 tablets daily. 
 Rifampicin/Isoniazid/Ethambutol hydrochloride 150mg/75mg/275mg Tablets should be swallowed 
with water or another drink. 
The tablets should be taken on an empty stomach (at least one hour prior to or two hours after a meal). 
 If you have a kidney-disease, your doctor may prescribe separate formulations of the component drugs 
in Rifampicin/Isoniazid/Ethambutol hydrochloride 150mg/75mg/275mg Tablets. 
Rifampicin/Isoniazid/Ethambutol hydrochloride 150mg/75mg/275mg Tablets is not recommended for 
patients with a body weight of less than 20 kg

SIDE EFFECTS AND SPECIAL PRECAUTIONS:

The most important adverse effects of isoniazid, rifampicin and ethambutol are nerve injuries and severe and sometimes fatal inflammation of the liver.

The most commonly reported side effects include sensations of tingling, pricking, or numbness of the skin, especially in the feet and hands.

Commonly reported side effects include a reddish discouloration of body fluids such as urine, sputum, tears, saliva and sweat. Further common side effects are diarrhoea, abdominal pain, loss of appetite, nausea and vomiting, as well as skin reactions with rash and/or itching, and disturbances of the menstrual cycle, ocular redness, permanent discolouration of soft contact lenses, visual disturbances due to the inflammation of the optic nerve.

Uncommon side effects are inflammation of the liver (hepatitis) epileptic seizures, headache, inflammation of the brain, personality changes and memory impairment. If you notice signs and symptoms suggestive of liver damage.

STORAGE INSTRUCTIONS:

Store below 25°C in a dry place, out of reach of children.